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991.
SHAHID Muhammad Qasim 《科学通报(英文版)》2010,55(13):1255-1262
Oryza rufipogon exhibits abundant genetic diversity and contains many elite genes. In this work, a total of 441 accessions of O. rufipogon were genetically examined using the functional marker S5n, revealing that 18 accessions carried the S5n allele with a heterozygous genotype (S5nS5i/j). Of these accessions, 14 were from Guangdong Province, 2 from Guangxi Zhuang Autonomous Region, 1 from Hainan Province and 1 from Jiangxi Province. Further sequence analysis spanning both sides of the deletion in S5n allel... 相似文献
992.
Antoni Camins Javier G. Pizarro Daniel Alvira Javier Gutierrez-Cuesta Aurelio Vazquez de la Torre Jaume Folch Francesc X. Sureda Ester Verdaguer Felix Junyent Joaquín Jordán Isidre Ferrer Mercè Pallàs 《Cellular and molecular life sciences : CMLS》2010,67(22):3865-3882
In the present study we demonstrated that neurotoxin MPP+-induced DNA damage is followed by ataxia telangiectasia muted (ATM) activation either in cerebellar granule cells (CGC) or in B65 cell line. In CGC, the selective ATM inhibitor KU-55933 showed neuroprotective effects against MPP+-induced neuronal cell loss and apoptosis, lending support to the key role of ATM in experimental models of Parkinson’s disease. Likewise, we showed that knockdown of ATM levels in neuroblastoma B65 cells using an ATM-specific siRNA attenuates the phosphorylation of retinoblastoma protein without affecting other cell-cycle proteins involved in the G0/G1 cell-cycle phase. Moreover, we demonstrated DNA damage, in human brain samples of PD patients. These findings support a model in which MPP+ leads to ATM activation with a subsequent DNA damage response and activation of pRb. Therefore, this study demonstrates a new link between DNA damage by MPP+ and cell-cycle re-entry through retinoblastoma protein phosphorylation. 相似文献
993.
This study examined the individual and simultaneous adsorption of SOx(SO2)and NOx(NO-NO2)on activated carbon prepared from waste palm shell.The adsorption process was examined in a fixed bed reactor at low temperatures(100 300°C).For individual adsorption without any catalytic activation,SOx showed good adsorption whereas NOx was very much poor.In the simultaneous adsorption of SOx and NOx,SOx showed greater adsorption affinity than NOx.For palm shell activated carbon(PSAC)impregnated with metal catalyst(Ni and Ce)the concentration adsorbed profile showed that the amount of SOx adsorbed decreased regularly,while the amount of the adsorbed NOx increased irregularly.The properties of the pure and impregnated PSAC were analyzed by BET,SEM and EDX.These investigations indicated that PSAC impregnated with metal catalyst is the determining factor in the adsorption of SOx and NOx simultaneously. 相似文献
994.
995.
996.
浅析公路桥梁建设的现状及安全对策 总被引:1,自引:1,他引:0
随着社会经济快速发展,公路也在高速发展,但在公路桥梁建设中存在不少问题.文章就公路桥梁建设中存在的问题进行深入浅出的分析,从而阐述了在建设中的安全对策. 相似文献
997.
安全管理工作的好坏.直接关系到铁路企业生产经营管理效果.通过分析宣传教育、管理体制、教育培训、管理制度和管理理念等方面存在的问题,提出做好安全管理的对策. 相似文献
998.
G. E. Callander R. A. D. Bathgate 《Cellular and molecular life sciences : CMLS》2010,67(14):2327-2341
Since its discovery in the 1920s, relaxin has enjoyed a reputation as a peptide hormone of pregnancy. However, relaxin and
other relaxin family peptides are now associated with numerous non-reproductive physiologies and disease states. The new millennium
bought with it the sequence of the human genome and subsequently new directions for relaxin research. In 2002, the ancestral
relaxin gene RLN3 was identified from genome databases. The relaxin-3 peptide is highly expressed in a small region of the brain and in species
from teleost to primates and has both conserved sequence and sites of expression. Combined with the discovery of the relaxin
family peptide receptors, interest in the role of the relaxin family peptides in the central nervous system has been reignited.
This review explores the relaxin family peptides that are expressed in or act upon the brain, the receptors that mediate their
actions, and what is currently known of their functions. 相似文献
999.
善于"疏导",深入到职工之中,倾听职工的心声,听取职工对改革的意见和建议,采用各种形式及时了解职工的思想动态及时分析、解决和化解矛盾,千方百计地稳定职工思想,促进职工转变不合时宜的观念,是确保公用事业改革顺利进行的关键所在. 相似文献
1000.
作为英美意识流小说的一位杰出代表,弗吉尼亚·伍尔夫一生致力于小说的改革和艺术的创新,追求表现人物的精神世界,并且成功地将意识流技巧运用于现代小说.<墙上的斑点>就是她最早发表的意识流短篇小说,正如"一叶落而知天下秋",它其中所展现的现代主义时空观念、现代主义叙事技巧和现代主义阐释空间使我们对现代主义美学特征有了更透彻的理解,也更加感受到了现代主义小说世界的魅力. 相似文献